Nursing Pharmacology 2018

A new anti-cancer drug may be effective against a wider range of cancers. Using a mouse model and samples taken from cancer patients, a team from the Technical University of Munich (TUM) has shown that a new class of drugs known as SHP2 inhibitors is hard-to-treat tumours such as lung and pancreatic cancers. The major role of this SHP2 inhibitors is that Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases Clinical trials currently underway had previously excluded patients with these cancers. Lung and pancreatic cancer are referred to as KRAS tumors, as they allowed the same genetic error. This error means that the KRAS protein, involved in, among other things, cell division, no longer works properly and is always active. As a result, the cells divide out of control, leading to tumor formation. KRAS tumors make up about a third of all tumors in humans. The problem, however, is that the KRAS protein is also active and plays a crucial ro...

Fournier, a professor at the University of Lille and co-director of a proteomics center of INSERM, the French national institute of health. In Her laboratory, she has worked for several years on a device. It was called “Spider Mass” that will enable the surgeons to identify markers of cancer in a living patient's tissue, during an operation. Surgery to remove a primary tumor and after some healthy surrounding tissue are removed, Although this process will help for preventing recurrence of the cancer, it can add up to 45 risky minutes under anesthesia. Fournier's device uses mass spectrometry method, which measures the mass of molecules from complex mixtures. But turning an in vivo tissue sample into gas phase ions for measurements can be a challenge. Until now, no one knew how to extract ions from living tissues without doing harm. Riffing on MALDI, it is an ionization strategy that uses a carrier molecule mixed with the analyte of interest; then they decided to ...

Medications are the most common treatment used in healthcare around the world. When used safely and appropriately, they contribute to significant improvements in the health and well-being of patients. Iatrogenic injuries related to medications are common, costly, and clinically significant. Computerized physician order entry (CPOE) and clinical decision support systems (CDSSs) may reduce medication error rates. They have undergone several clinical trial methods. Methods Adapted: The researchers Rainu Kaushal, MD, MPH; Kaveh G. Shojania, MD; David W. Bates, MD, MSc, were identified clinical trials that evaluated the effects of Computerized physician order entry (CPOE) and clinical decision support systems (CDSSs) on medication safety by electronically searching MEDLINE and the Cochrane Library and by manually searching the bibliographies of retrieved articles. Studies were included for systematic review if the design was a randomized controlled trial, a nonrandomized cont...

Mycetoma is a severe infection of skin and it can also cause some chronic infection to the subcutaneous tissue. The condition was first described in the region of Madura in India where the disease was first identified. Mycetoma is also a tropical disease; it can cause severe disfigurement and disability if it is not treated early. Mycetoma can be caused by any of 70 fungi or actinomycetes bacteria. In all cases, chronic and progressive infection and inflammation cause masses under the skin which can spread to deeper structures including bone. Sudan has one of the highest rates of mycetoma endemicity in the world, though the disease is found throughout the tropics and subtropics. Mycetoma patients are often hindered from timely and appropriate treatment by financial limitations and geographic remoteness from regional health facilities. In this work had done by Ahmed Fahal, from the University of Khartoum, Sudan, and his colleagues at the Myectoma Research Centre (MRC) a...

Traditional Chinese medicine is a style of medicine that built on a foundation of more than 2,500 years of Chinese medical practice. It includes various forms of natural and herbal medicine, but recently it was influenced by modern Western medicine. TCM is widely used in China and is becoming increasingly popular and recognized worldwide. A medicinal plant which is frequently used in Traditional Chinese Medicine (TCM) is -- Evodia rutaecarpa – that contains substances can cause cardiac arrhythmia. It was found by the researchers from Universities of Basel, Vienna. The plant Extracts from Evodia rutaecarpa that are used in Traditional Chinese Medicine for a variety of symptoms, such as headaches and vomiting sensation as well as menstrual complaints and ulcers. The Professor Matthias Hamburger from the Department of Pharmaceutical Sciences at the University of Basel who discovered the effect of Evodia plant extracts with the help of pharmacologists and toxicologis...

A research survey says that one in 3 patients is estimated to experience health care–related harm during hospitalization. This cross-sectional study used to measure interprofessional staff perceptions of safety and teamwork climate, modified Global Trigger Tool chart review methodology to measure unit-level patient outcomes. The word Global Trigger Tool is used to identify the adverse events for measuring the overall level of effects caused by the harmful products in healthcare industries. Researchers may consider this Global Trigger tool for detecting the unit- level adverse events. Measuring Safety climate, Team Work Climate and Adverse Events (AEs): Safety climate is the value for safety requirement in an organisation at a particular point in time. These perceptions can be influenced by the attitudes, values, opinions and actions of other workers in an organisation, and can change with time and circumstance. The relationship between the patient outcome and Safety clim...