Nursing Pharmacology 2018

Genetic Mutation – Prevent people from Malaria Scientists at The Scripps Research Institute (TSRI) The Scripps Research Institute (TSRI) are one of the world's largest independent, not-for-profit organizations focusing on research in the biomedical sciences. Scientists discovered a Genetic mutation that may protect people from malaria. It was thought to be rare. They suggest a finding on how humans who live in close quarters with malaria-carrying mosquitos may evolve defences against the disease. They have identified a gene PIEZO1, which codes for pressure sensing protein. It dehydrates the red blood cells. In mouse this mutation might be  harder for malaria parasite and plasmodium to infect red cells then it will cause cerebral malaria (a severe neurological complication of Plasmodium infection) this dehydration condition is called xerocytosis and it was thought to be extremely rare, so the researchers were find it could be present in one in three people of Afr...

Researchers from Louisiana State University have developed a systematic way to find existing drugs for fight against the rare diseases. Chemotherapeutic vandetanib is an effective target of Protein kinase 6. This protein is involved in many cancers including gastrointestinal tumours and ovarian cancers . The researchers have derived PTK6 complex and vandetanib by protein modelling. Through protein modelling the researchers at LSU have found the KRAS protein which is also have a similar drug/protein binding site and it would be a match for a same drug. It helps in protein structure and function predictions. They have adapted computer aided drug re-positioning process for the identification of the binding site of that particular drug target protein. Rare diseases treatment sometimes would not be curable due to the financial feasibility so these are sometimes left untreated. The purpose of computational protein modelling is to find the matches between the protein struct...

Recent Research on Pharmacology:   A New Drug Could Prevent Hearing Loss Researchers have discovered a new drug to cure hearing loss is the current research on pharmacology. Cyclin-dependent kinase 2 (CDK2) is an enzyme will induce the hearing loss in mice. The recent study states that this inhibitor will prevent the death of inner ear cells. Researchers from St. Jude Children's Research Hospital have discovered the enzyme called cyclin-dependent kinase 2 (CDK2) which protects drug-induced hearing loss in human. This was published on March 7 in the Journal of Experimental Medicine by Dr. Jian Zuo. For their research work almost they screened over 4,000 drugs for to protect cochlea r cells from cisplatin which is the chemotherapy agent used for to treat cancer. It will cause irreversible hearing loss. They identified multiple compounds for the prevention of cochlear cells. CDK2 has three inhibitors, in that kenpaullone was more effective than others. Remainin...

Current Research: ADHD (attention-deficit hyperactivity disorder)  Attention Deficit Hypersensitivity Disorder is a brain disorder. This disease was found in adolescents with attention problem and Hyperactivity. When we hear about this term hyperactivity many of them think that this is not a case. It is normal to have some inattention, if it is more severe than it became noticeable one. According to the Center for Disease Control report approximately 5.4 million children ranging from age 4 through 17 have been diagnosed with this type of ADHD disease. The symptoms can vary for every person. Diagnosis of ADHD requires a comprehensive evaluation by a licensed clinician such as pediatrician. Scientists are trying to find the solution for this behavioural disease. While there is no cure for this  disease. Through medications we can reduce the hyperactivity and impulsivity. One of the most common type of medication is Stimulant. It will increase the bra...